564 Subpopulations of dermal fibroblasts produce distinct extracellular matrices
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چکیده
منابع مشابه
Cultured human dermal fibroblasts do produce cortisol.
TO THE EDITOR Known steroidogenic functions of the skin that are represented by the synthesis and metabolism of androgens and estrogens (Chen et al., 2002; Zouboulis and Degitz, 2004) probably include corticosteroids (Slominski et al., 2000; Slominski, 2005). Thus, the skin expresses both the genes and proteins involved in the synthesis of adrenal corticosteroids (Slominski et al., 1996, 1999, ...
متن کاملSkin telocytes versus fibroblasts: two distinct dermal cell populations
It is already accepted that telocytes (TCs) represent a new type of interstitial cells in human dermis. In normal skin, TCs have particular spatial relations with different dermal structures such as blood vessels, hair follicles, arrector pili muscles or segments of sebaceous and/or eccrine sweat glands. The distribution and the density of TCs is affected in various skin pathological conditions...
متن کاملSpatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations
Previous studies have shown that mouse dermis is composed of functionally distinct fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used a combination of comparative spatial transcriptional profiling of human and mouse dermis and single-cell transcriptional profiling of human dermal fibroblasts. We show that there are at least four distinct fibroblast pop...
متن کاملStimulation of the extracellular matrix production in dermal fibroblasts by velvet antler extract.
BACKGROUND Fibroblasts produce many components of the extracellular matrix (ECM) and so they contribute to the maintenance of connective tissue integrity. OBJECTIVE The aim of this study is to evaluate the effect of velvet antler extract (VAE) on the ECM production of dermal fibroblasts cultured in vitro. METHODS Primary cultured human dermal fibroblasts were treated with VAE, and then the ...
متن کاملAcceleration of Collagen Breakdown by Extracellular Basic pH in Human Dermal Fibroblasts.
BACKGROUND/AIMS Wound healing is a complex regeneration process involving the degradation and reassembly of connective tissues and skin layers. Previous studies have shown that pH plays a significant role in both the direct and indirect regulation of cellular processes in the wound, which, in turn, affect the wound healing process. However, the effects of pH on the collagen breakdown component o...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.06.588